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Agnes Brown Duggan Endowed Chair of Oncological Research, James Graham Brown Cancer Center; Professor of Pharmacology & Toxicology; Senior Scientist, James Graham Brown Cancer Center
Research ProgramPrevention & Control
Education
Education/Training
B.Sc., Meerut University, India, Chem/Phys/Maths, 1967
M.Sc., Meerut University, India, Chem (Physical), 1969
Ph.D., University of Roorkee, India, Mech. of Oxidation of Aromatic Aminies, 1972
Post-Doc, Baylor College of Medicine, Houston, TX, Novel Techniques for Sequencing tRNAs, 1973-1976
Research and Professional Experience
1973-1976
Research Associate
1977-1978
Instructor
1978-1989
Assistant Professor and Associate Professor, Baylor College of Medicine
1989-2003
Professor, Preventive Medicine & Environmental Health, Professor in Graduate Center for Toxicology
1998-Present
Faculty Member, Nutritional Science Program, University of Kentucky, Lexington, KY
2003
Professor and Agnes Brown Duggan Chair of Oncological Research, Department of Pharmacology & Toxicology and the Brown Cancer Center, University of Louisville Medical School, Louisville
2003
Member and Head of the Biomarkers, Genetics & Chemoprevention Group, Prevention & Control Program, James Graham Brown Cancer Center, University of Louisville
June 2004
Director of Genetic Susceptibility & Biomarkers Research Core,
University of Louisville
Selected Awards and Professional Honors
Honors in Chemistry and Math, Valedictorian (Gold Medalist) in Master's Program
Merit Scholarship Recipient in B.Sc., M.Sc. and Ph.D. programs
In top 1-2% in High School and College
1981-1982
Our PNAS and Carcinogenesis papers selected for the 1983 and 1984 Year Book of Cancer
1988
PNAS paper selected for the 1990 Year Book of Occupational Medicine
1990
Featured in Cancer Research for co-developing the 32P-Postlabeling DNA Adduct Assay
1990-92
Guest Professor at the Institute of Toxicology, ETH and University of Zurich, Switzerland International Agency for Research on Cancer (IARC), Lyon, France
1996-98
Institute of Toxicology, University of Wuerzburg Medical School, Wuerzburg, Germany
2002-2003
Recipient of Charles W. Wethington, Jr. Award for Research Accomplishments
2003-present
Distinguished University Scholar
2003-present
Agnes Brown Duggan Chair in Oncological Research
PublicationsArif JM, Gairola CG, Glauert HP, Kelloff GJ, Lubet RA, Gupta RC. Inhibition of cigarette smoke-related lipophilic DNA adducts in rat tissues by indole-3-carbinol. Mutat Res 452:11-18, 2000
Smith WA, Arif JM, Gupta RC. 1,2-Dithiol-3-thione and its structural analogue oltipraz are potent inhibitors of dibenz[a,l]pyrene-DNA adduction in female S/D rats. Internatl J Cancer 91:132-36, 2001
Smith WA, Freeman JW, Gupta RC. Effects of chemopreventive agents on DNA adduction induced by the potent mammary carcinogen dibenz[a,l]pyrene in the human breast cells MCF-7. Mutat Res 480-481:97-108, 2001
Gupta RC, Arif JM. An improved 32P-postlabeling assay for the sensitive detection of 8-oxodeoxyguanosine in tissue DNA. Chem Res Toxicol 14(8):951-7, 2001.
Fang AH, Smith WA, Vouros P, Gupta RC. Identification and characterization of a novel benzo[a]pyrene-derived DNA adduct. Biochem Biophys Res Commun 281:383-9, 2001
Pereg D, Robertson LW, Gupta RC. Direct DNA adduction from in vitro bioactivation of PCBs in microsomal systems: Cross-species comparison. Chem-Biol Interact 139:129-44, 2002
Srinivasan P, Vadhanam M, Arif JM, Gupta RC. A rapid screening assay for antioxidant potential of natural and synthetic agents in vitro, Internatl J Oncology 20:983-86, 2002
Arif JM, Lehmler H-J, Robertson LW, Gupta RC. Interaction of benzoquinone- and hydroquinone-derivatives of lower chlorinated biphenyls with DNA and nucleotides in vitro. Chem-Biol Interact 142:307-316, 2003
Arif JM, Gupta RC. Artifactual formation of 8-oxo-2'-deoxyguanosine: role of fluorescent light and inhibitors. Oncol Rep 10:2071-74, 2003
Vadhanam MV, Horn J, Flesher JW, Gupta RC. Detection of nenzylic adducts in DNA and nucleotides from 7-sulfooxymethyl-12-methylbenz[a]anthracene and related compounds by 32P-postlabeling using new TLC systems. Chem-Biol Interact 146:81-87, 2003
Gennaro LA, Vadhanam MV, Gupta RC, Vouoros P. Selective digestion and novel cleanup techniques for detection of benzo[a]pyrene diol epoxide-DNA adducts by CE/MS. Rapid Commun Mass Spect 18:1541-47, 2004
Ravi Kumar MN, Vadhanam MV, Horn J, Flesher JW, Gupta RC. Formation of benzylic-DNA adducts resulting from 7,12-dimethylbenz[a]anthracene in vivo. Chem Res Toxicol 18(4):686-91, 2005
Thaiparambil JT, Vadhanam MV, Srinivasan C, Gairola CG, Gupta RC. Time-dependent formation of 8-oxo-deoxyguanosine in the lungs of mice exposed to cigarette smoke. Chem Res Toxicol 20(12):1737-40, 2007
Ravoori S, Vadhanam MV, Sahoo S, Srinivasan C, Gupta RC. Mammary tumor induction in ACI rats exposed to low levels of 17beta-estradiol. Int J Oncol ;31(1):113-20, 2007
Ravoori S, Feng Y, Neale JR, Jeyabalan J, Srinivasan C, Hein DW, Gupta RC. Dose-dependent reduction of 3,2'-dimethyl-4-aminobiphenyl-derived DNA adducts in colon and liver of rats administered celecoxib. Mutat Res 638(1-2):103-9, 2008
Aiyer HS, Srinivasan C, Gupta RC. Dietary berries and ellagic acid diminish estrogen-mediated mammary tumorigenesis in ACI rats. Nutr Cancer 60(2):227-34, 2008.
Contact InfoBaxter II Biomedical Research Building
580 South Preston Street
Louisville, KY 40202
Phone: (502) 852-3682
Fax: (502) 852-3661
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